昆虫免疫：从双翅目昆虫嗜尸性麻蝇的免疫血液中分离出两种与兔肺巨噬细胞杀菌肽具有序列同源性的昆虫抗菌肽。
Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.
作者信息
Lambert J, Keppi E, Dimarcq J L, Wicker C, Reichhart J M, Dunbar B, Lepage P, Van Dorsselaer A, Hoffmann J, Fothergill J
机构信息
Unité Associée au Centre National de la Recherche Scientifique, Laboratoire de Biologie Générale, Strasbourg, France.
出版信息
Proc Natl Acad Sci U S A. 1989 Jan;86(1):262-6. doi: 10.1073/pnas.86.1.262.
Abstract
We have isolated from the hemolymph of immunized larvae of the dipteran insect Phormia terranovae two peptides that are selectively active against Gram-positive bacteria. They are positively charged peptides of 40 residues containing three intramolecular disulfide bridges and differ from one another by only a single amino acid. These peptides are neither functionally nor structurally related to any known insect immune response peptides but show significant homology to microbicidal cationic peptides from mammalian granulocytes (defensins). We propose the name "insect defensins" for these insect antibiotic peptides.
摘要
我们从双翅目昆虫新大陆绿蝇免疫幼虫的血淋巴中分离出两种对革兰氏阳性菌具有选择性活性的肽。它们是由40个氨基酸残基组成的带正电荷的肽，含有三个分子内二硫键，彼此之间仅相差一个氨基酸。这些肽在功能和结构上与任何已知的昆虫免疫反应肽均无关联，但与哺乳动物粒细胞的杀菌阳离子肽（防御素）具有显著的同源性。我们为这些昆虫抗菌肽提议命名为“昆虫防御素”。
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