Kalaiarasi Arunachalam, Sankar Renu, Anusha Chidambaram, Saravanan Kandasamy, Aarthy Kalyanasundaram, Karthic Selvaraj, Mathuram Theodore Lemuel, Ravikumar Vilwanathan
Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, USA.
Biotechnol Lett. 2018 Feb;40(2):249-256. doi: 10.1007/s10529-017-2463-6. Epub 2017 Nov 7.
Copper oxide nanoparticles (CuO NPs) promoting anticancer activity may be due to the regulation of various classes of histone deacetylases (HDACs).
Green-synthesized CuO NPs significantly arrested total HDAC level and also suppressed class I, II and IV HDACs mRNA expression in A549 cells. A549 cells treated with CuO NPs downregulated oncogenes and upregulated tumor suppressor protein expression. CuO NPs positively regulated both mitochondrial and death receptor-mediated apoptosis caspase cascade pathway in A549 cells.
Green-synthesized CuO NPs inhibited HDAC and therefore shown apoptosis mediated anticancer activity in A549 lung cancer cell line.
氧化铜纳米颗粒（CuO NPs）促进抗癌活性可能归因于对各类组蛋白去乙酰化酶（HDACs）的调节。
绿色合成的CuO NPs显著抑制了A549细胞中总HDAC水平，并抑制了I、II和IV类HDACs的mRNA表达。用CuO NPs处理的A549细胞下调了癌基因并上调了肿瘤抑制蛋白的表达。CuO NPs在A549细胞中正向调节线粒体和死亡受体介导的凋亡半胱天冬酶级联途径。
绿色合成的CuO NPs抑制了HDAC，因此在A549肺癌细胞系中显示出凋亡介导的抗癌活性。
