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通过共沉淀法制备用于抗癌活性的CdO-CuO-ZnO混合金属氧化物纳米复合材料

Tailoring CdO-CuO-ZnO Mixed Metal Oxide Nanocomposites for Anticancer Activity via Co-Precipitation Method.

作者信息

Aziz Shadha Nasser, Abdulwahab Abduh Mohammad, Shuga Aldeen Thana, Ahmed Abdullah Ahmed Ali

机构信息

Physics Department, Faculty of Science, Sana'a University, Sana'a, Yemen.

Department of Basic Sciences, Al-Darb Community College, Dhamar, Yemen.

出版信息

Nanotechnol Sci Appl. 2025 May 7;18:225-244. doi: 10.2147/NSA.S519229. eCollection 2025.

DOI:10.2147/NSA.S519229
PMID:40357522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12067457/
Abstract

INTRODUCTION

The use of metal oxide nanoparticles as anticancer agents is of great interest due to their unique properties that allow targeted delivery at low concentrations with minimal toxicity to healthy cells.

METHODS

In this work, CdO-CuO-ZnO mixed metal oxide nanocomposites were synthesized by the co-precipitation method, and their structural and optical properties, along with their anticancer activity, were investigated. The samples were characterized by X-ray diffraction (XRD), total reflection X-ray fluorescence (TXRF), transmission electron microscopy (TEM), selected area electron diffraction (SAED), UV-Vis spectroscopy, electrometer/high resistance material, and vibrating sample magnetometers (VSM).

RESULTS

X-ray diffraction (XRD) measurements showed that CdO exhibits a cubic structure, CuO possesses a monoclinic structure, ZnO displays a hexagonal structure, and the mixture showed peaks corresponding to all three oxides. TEM images revealed that the prepared nanoparticles have quasi-spherical shapes. Anticancer studies confirmed that the CdO-CuO-ZnO nanocomposite demonstrates excellent cytotoxicity, with moderate activity against human colon (Caco-2) and lung (A549) cancer cell lines, exhibiting IC50 values of 10.57 μg/mL and 6.61 μg/mL, respectively.

CONCLUSION

Our study shows that the prepared CdO-CuO-ZnO nanocomposite has massive potential in cancer therapy.

摘要

引言

金属氧化物纳米颗粒作为抗癌剂的应用备受关注，因为它们具有独特的性质，能够在低浓度下实现靶向递送，对健康细胞的毒性最小。

方法

在本研究中，采用共沉淀法合成了CdO-CuO-ZnO混合金属氧化物纳米复合材料，并对其结构、光学性质以及抗癌活性进行了研究。通过X射线衍射（XRD）、全反射X射线荧光光谱（TXRF）、透射电子显微镜（TEM）、选区电子衍射（SAED）、紫外可见光谱、静电计/高电阻材料以及振动样品磁强计（VSM）对样品进行了表征。

结果

X射线衍射（XRD）测量表明，CdO呈现立方结构，CuO具有单斜结构，ZnO显示六方结构，混合物显示出对应于所有三种氧化物的峰。透射电子显微镜（TEM）图像显示，制备的纳米颗粒具有准球形形状。抗癌研究证实，CdO-CuO-ZnO纳米复合材料表现出优异的细胞毒性，对人结肠（Caco-2）和肺癌（A549）细胞系具有中等活性，IC50值分别为10.57μg/mL和6.61μg/mL。

结论

我们的研究表明，制备的CdO-CuO-ZnO纳米复合材料在癌症治疗中具有巨大潜力。

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