NFIL 调节宿主生物钟-微生物精细调节上皮钟。

NFIL-trating the Host Circadian Rhythm-Microbes Fine-Tune the Epithelial Clock.

机构信息

Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.

出版信息

Cell Metab. 2017 Nov 7;26(5):699-700. doi: 10.1016/j.cmet.2017.10.014.

DOI:10.1016/j.cmet.2017.10.014

Abstract

The diurnal activities of the intestinal microbiota and its host are closely connected, but the nature of their circadian communication pathways remains obscure. Wang et al. (2017) have described a signaling circuit linking microbial sensing by the immune system to the epithelial clock, thereby orchestrating local and systemic lipid metabolism.

摘要

肠道微生物群及其宿主的昼夜活动密切相关，但它们的生物钟通讯途径的性质仍不清楚。Wang 等人（2017 年）描述了一个信号通路，将免疫系统对微生物的感应与上皮生物钟联系起来，从而协调局部和全身的脂质代谢。