肠道菌群作为代谢的生物钟协调者。
The Microbiome as a Circadian Coordinator of Metabolism.
机构信息
Microbiology Department, Institute for Immunology, and Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Endocrinology. 2020 Jun 1;161(6). doi: 10.1210/endocr/bqaa059.
The microbiome is critically involved in the regulation of systemic metabolism. An important but poorly understood facet of this regulation is the diurnal activity of the microbiome. Herein, we summarize recent developments in our understanding of the diurnal properties of the microbiome and their integration into the circadian regulation of organismal metabolism. The microbiome may be involved in the detrimental consequences of circadian disruption for host metabolism and the development of metabolic disease. At the same time, the mechanisms by which microbiome diurnal activity is integrated into host physiology reveal several translational opportunities by which the time of day can be harnessed to optimize microbiome-based therapies. The study of circadian microbiome properties may thus provide a new avenue for treating disorders associated with circadian disruption from the gut.
微生物组在调节全身代谢中起着至关重要的作用。这种调节的一个重要但尚未被充分理解的方面是微生物组的昼夜活动。本文总结了我们对微生物组昼夜特性及其与机体代谢昼夜节律调节整合的最新认识。微生物组可能与昼夜节律紊乱对宿主代谢和代谢性疾病发展的有害后果有关。与此同时，微生物组昼夜活动整合到宿主生理学中的机制揭示了几种转化机会，即可以利用一天中的时间来优化基于微生物组的治疗。因此，研究昼夜微生物组特性可能为从肠道治疗与昼夜节律紊乱相关的疾病提供新途径。
Zotero 插件