Tetteh Ato Kwamena, Agyarko Edward
Laboratory Department, Metropolitan Hospital, P.O. Box 174, Cape Coast, Ghana.
Department of Community Medicine and Health, Anglican University College of Technology, P.O. Box 74, Nkoranza, Ghana.
J Sex Transm Dis. 2017;2017:2857397. doi: 10.1155/2017/2857397. Epub 2017 Oct 8.
Screening results of 488 pregnant women aged 15-44 years whose blood samples had been tested on-site, using First Response® HIV 1/2, and confirmed with INNO-LIA™ HIV I/II Score were used. Of this total, 178 were reactive (HIV I, 154; HIV II, 2; and HIV I and HIV II, 22). Of the 154 HIV I-reactive samples, 104 were confirmed to be HIV I-positive and 2 were confirmed to be HIV II-positive, while 48 were confirmed to be negative [false positive rate = 17.44% (13.56-21.32)]. The two HIV II samples submitted were confirmed to be negative with the confirmatory test. For the 22 HIV I and HIV II samples, 7 were confirmed to be HIV I-positive and 1 was confirmed to be HIV I- and HIV II-positive, while 14 were confirmed to be negative. Of the 310 nonreactive samples, 6 were confirmed to be HIV I-positive and 1 was confirmed to be HIV II-positive [false negative rate = 5.79% (1.63-8.38)], while 303 were negative. False negative outcomes will remain unconfirmed, with no management options for the client. False negative rate of 5.79% requires attention, as its resultant implications on control of HIV/AIDS could be dire.
对488名年龄在15 - 44岁的孕妇进行了筛查，这些孕妇的血样在现场使用First Response® HIV 1/2进行检测，并通过INNO-LIA™ HIV I/II Score进行确认。在这488名孕妇中，178名检测呈反应性（HIV I型，154例；HIV II型，2例；HIV I型和HIV II型，22例）。在154例HIV I型反应性样本中，104例被确认为HIV I型阳性，2例被确认为HIV II型阳性，48例被确认为阴性[假阳性率 = 17.44%（13.56 - 21.32）]。送检的2例HIV II型样本经确证试验确认为阴性。对于22例HIV I型和HIV II型样本，7例被确认为HIV I型阳性，1例被确认为HIV I型和HIV II型阳性，14例被确认为阴性。在310例非反应性样本中，6例被确认为HIV I型阳性，1例被确认为HIV II型阳性[假阴性率 = 5.79%（1.63 - 8.38）]，303例为阴性。假阴性结果将无法得到确认，客户也没有处理办法。5.79%的假阴性率需要引起关注，因为其对艾滋病毒/艾滋病控制的影响可能是严重的。
