Simeoni Chiara, Dinicola Simona, Cucina Alessandra, Mascia Corrado, Bizzarri Mariano
Department of Mathematics, University of Nice Sophia Antipolis, Parc Valrose, 06108, Nice Cedex 02, France.
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy.
Methods Mol Biol. 2018;1702:95-123. doi: 10.1007/978-1-4939-7456-6_7.
In this report, we aim at presenting a viable strategy for the study of Epithelial-Mesenchymal Transition (EMT) and its opposite Mesenchymal-Epithelial Transition (MET) by means of a Systems Biology approach combined with a suitable Mathematical Modeling analysis. Precisely, it is shown how the presence of a metastable state, that is identified at a mesoscopic level of description, is crucial for making possible the appearance of a phase transition mechanism in the framework of fast-slow dynamics for Ordinary Differential Equations (ODEs).
在本报告中，我们旨在通过系统生物学方法与适当的数学建模分析相结合，提出一种用于研究上皮-间质转化（EMT）及其相反过程间质-上皮转化（MET）的可行策略。具体而言，展示了在介观描述水平上识别出的亚稳态的存在如何对于在常微分方程（ODE）的快慢动力学框架中使相变机制的出现成为可能至关重要。
