Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, The Institute for Advanced Studies, and Wuhan Institute of Biotechnology, Wuhan University , Wuhan 430072, P. R. China.
ACS Appl Mater Interfaces. 2017 Nov 22;9(46):39901-39906. doi: 10.1021/acsami.7b09557. Epub 2017 Nov 9.
Monodisperse hydrophilic quantum dots (QDs) are promising labeling materials for biomedical applications. However, the controllable preparation of monodisperse hydrophilic QDs with amphiphilic polymers remains a challenge. Herein, the molecular structures of amphiphilic polymers assembled on different-sized QDs are investigated. Both the experimental results and the molecular dynamics (MD) calculation suggest that the grafting ratio of amphiphilic polymers assembled on QDs increases as the size of QDs increases. Thus, the controllable preparation of different-sized monodisperse hydrophilic QDs can be achieved by simply varying the grafting ratio of amphiphilic molecules and applied in the simultaneous labeling of three tumor biomarkers.
单分散亲水性量子点（QD）是一种很有前途的生物医学应用标记材料。然而，可控制备具有两亲性聚合物的单分散亲水性 QD 仍然是一个挑战。在此，研究了组装在不同尺寸 QD 上的两亲聚合物的分子结构。实验结果和分子动力学（MD）计算都表明，组装在 QD 上的两亲聚合物的接枝率随 QD 尺寸的增加而增加。因此，可以通过简单地改变两亲分子的接枝率来制备不同尺寸的单分散亲水性 QD，并应用于同时标记三种肿瘤生物标志物。
