Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran.
Biol Trace Elem Res. 2024 May;202(5):2391-2401. doi: 10.1007/s12011-023-03819-5. Epub 2023 Aug 19.
Alendronate-functionalized graphene quantum dots (ALEN-GQDs) with a quantum yield of 57% were synthesized via a two-step route: preparation of graphene quantum dots (GQDs) by pyrolysis method using citric acid as the carbon source and post functionalization of GQDs via a hydrothermal method with alendronate sodium. After careful characterization of the obtained ALEN-GQDs, they were successfully employed as sensing materials with superior selectivity and sensitivity for the detection of nanomolar levels of arsenic ions (As(III)). According to the mechanistic investigation, arsenic ions can quench the fluorescence intensity of ALEN-GQDs through metal-ligand interaction between the As(III) ions and the surface functional groups of the fluorescent probe. This probe provided a rapid method to monitor As(III) with a wide detection range (44 nM-1.30 µM) and a low detection limit of 13 nM. Finally, to validate the applicability, this novel fluorescent probe was successfully applied for the quantitative determination of As(III) in rice and water samples.
通过两步法合成了量子产率为 57%的阿仑膦酸钠功能化石墨烯量子点（ALEN-GQDs）：首先采用柠檬酸作为碳源通过热解法制备石墨烯量子点（GQDs），然后通过水热法用阿仑膦酸钠对 GQDs 进行后功能化。在对所得到的 ALEN-GQDs 进行了仔细的表征后，它们被成功用作传感材料，具有优异的选择性和灵敏度，可用于检测纳摩尔级别的砷离子（As(III)）。根据机理研究，砷离子可以通过 As(III)离子与荧光探针表面官能团之间的金属-配体相互作用来猝灭 ALEN-GQDs 的荧光强度。该探针提供了一种快速监测 As(III)的方法，具有较宽的检测范围（44 nM-1.30 μM）和低检测限 13 nM。最后，为了验证适用性，该新型荧光探针成功地用于稻米和水样中 As(III)的定量测定。
