亮叶槲寄生的羽扇豆烷型三萜类化合物。

Lupane-Type Triterpenes of Phoradendron vernicosum.

作者信息

Valencia-Chan Lía S, García-Cámara Isabel, Torres-Tapia Luis W, Moo-Puc Rosa E, Peraza-Sánchez Sergio R

机构信息

Unidad de Biotecnología, Centro de Investigación Científica de Yucatán (CICY) , Calle 43 No. 130, Col. Chuburná de Hidalgo, Mérida, Yucatán, México 97205.

Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad, Centro Médico Ignacio García Téllez, Instituto Mexicano del Seguro Social (IMSS) , Calle 41 No. 439, Col. Industrial, Mérida, Yucatán, México 97200.

出版信息

J Nat Prod. 2017 Nov 22;80(11):3038-3042. doi: 10.1021/acs.jnatprod.7b00177. Epub 2017 Nov 9.

DOI:10.1021/acs.jnatprod.7b00177

PMID:29120172

Abstract

Three new lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxolup-20(29)-en-28-oic acid (2), and 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), together with eight known compounds (4-11) were isolated from a methanol extract of Phoradendron vernicosum aerial parts. The chemical structures of 1-3 were determined on the basis of spectroscopic data interpretation. The isolated compounds were tested against seven human cancer cell lines and two normal cell lines.

摘要

从毛叶桑寄生地上部分的甲醇提取物中分离出三种新的羽扇豆烷型三萜化合物，即3α,24-二羟基羽扇-20(29)-烯-28-酸（1）、3α,23-二羟基-30-氧代羽扇-20(29)-烯-28-酸（2）和3α,23-O-亚异丙基-3α,23-二羟基羽扇-20(29)-烯-28-酸（3），以及八种已知化合物（4-11）。通过光谱数据解析确定了1-3的化学结构，并对分离得到的化合物进行了七种人类癌细胞系和两种正常细胞系的测试。