Bakr Hoda G, Salem Ihab M, Meawed Takwa E, Anis Reham H, El-Hefnawy Mohamed H
Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Egypt J Immunol. 2017 Jan;24(1):119-130.
Type 1 diabetic patients are vulnerable for autoimmune thyroid disease. The incidence of type I Diabetes in Egypt is 8/100000. Undiagnosed thyroid dysfunction impairs metabolic status and increase cardiovascular risks in diabetic patients. Objectives of the study were to underscore autoimmune thyroiditis and thyroid dysfunction on a sample of Egyptian type I diabetes mellitus. One hundred type 1 diabetic subjects without previously known thyroid diseases and 50 controls were included. Physical examination, HbA1c, thyroid profile (TSH, free T3 and free T4), thyroid ultrasound anti-peroxidase and anti-thyroglobulin antibodies were assessed. Autoimmune thyroiditis was detected in 27 % of the patients, and significantly associated with parental consanguinity, familial autoimmune disease and goiter. It is concluded that autoimmune thyroiditis is evident on laboratory assessment of type 1 diabetic patients who were apparently euthyroid. Screening of type I diabetics for thyroid diseases should be done even in absence of clinical evidence for better glycemic control and to improve long term outcome.
1型糖尿病患者易患自身免疫性甲状腺疾病。埃及1型糖尿病的发病率为8/100000。未诊断出的甲状腺功能障碍会损害代谢状态，并增加糖尿病患者的心血管风险。本研究的目的是强调埃及1型糖尿病患者样本中的自身免疫性甲状腺炎和甲状腺功能障碍。纳入了100名既往无甲状腺疾病的1型糖尿病受试者和50名对照。评估了体格检查、糖化血红蛋白、甲状腺功能指标（促甲状腺激素、游离三碘甲状腺原氨酸和游离甲状腺素）、甲状腺超声、抗过氧化物酶和抗甲状腺球蛋白抗体。27%的患者检测到自身免疫性甲状腺炎，且与近亲结婚、家族性自身免疫性疾病和甲状腺肿显著相关。结论是，在明显甲状腺功能正常的1型糖尿病患者的实验室评估中，自身免疫性甲状腺炎很明显。即使没有临床证据，也应对1型糖尿病患者进行甲状腺疾病筛查，以实现更好的血糖控制并改善长期预后。
