Veite-Schmahl Michelle J, Rivers Adam C, Regan Daniel P, Kennedy Michael A
Department of Chemistry & Biochemistry, Miami University, Oxford, Ohio, United States of America.
PLoS One. 2017 Nov 9;12(11):e0187552. doi: 10.1371/journal.pone.0187552. eCollection 2017.
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading forms of cancer related deaths in the United States. With limited treatment options and unreliable diagnostic methods, long-term survival rates following a diagnosis of pancreatic cancer remain poor. Pancreatic intraepithelial neoplasia (PanIN) are precancerous lesions that precede progression towards PDAC. PanIN occur in increasing complexity as the disease progresses and the description of PanIN plays a critical role in describing, staging and diagnosing PDAC. Inconsistencies in PanIN classifications exist even amongst leading pathologists. This has led to debate and confusion among researchers and pathologists involved in pancreatic cancer research, diagnosis and treatment. We have sought to initiate a discussion with leading pathologists with a goal of increasing consensus in the interpretation of PanIN and associated structures within the precancerous pancreas. Toward achieving this goal, we are in the process of conducting an extensive study of over 1000 male and female pancreata in varying stages of PanIN progression isolated from the Ptf1aCre/+;LSL-KrasG12D/+ transgenic mouse model of pancreatic cancer. Using this extensive database, we have established the Mouse Model of Pancreatic Cancer Atlas (MMPCA) to serve as a platform for meaningful and interactive discussion among researchers and pathologists who study pancreatic disease. We hope that the MMPCA will be an effective tool for promoting a more consistent and accurate consensus of PanIN classifications in the future.
胰腺导管腺癌（PDAC）是美国癌症相关死亡的主要形式之一。由于治疗选择有限且诊断方法不可靠，胰腺癌诊断后的长期生存率仍然很低。胰腺上皮内瘤变（PanIN）是向PDAC进展之前的癌前病变。随着疾病进展，PanIN的复杂性增加，对PanIN的描述在PDAC的描述、分期和诊断中起着关键作用。即使在顶尖病理学家中，PanIN分类也存在不一致之处。这在参与胰腺癌研究、诊断和治疗的研究人员和病理学家中引发了争论和困惑。我们试图与顶尖病理学家展开讨论，目的是在对癌前胰腺中的PanIN及相关结构的解读上达成更多共识。为实现这一目标，我们正在对从胰腺癌的Ptf1aCre/+;LSL-KrasG12D/+转基因小鼠模型中分离出的1000多个处于PanIN不同进展阶段的雄性和雌性胰腺进行广泛研究。利用这个庞大的数据库，我们建立了胰腺癌图谱小鼠模型（MMPCA），作为研究胰腺疾病的研究人员和病理学家进行有意义的互动讨论的平台。我们希望MMPCA将来能成为促进对PanIN分类达成更一致、准确共识的有效工具。
