无义介导的 mRNA 降解与癌症。
Nonsense-mediated mRNA Decay and Cancer.
机构信息
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
出版信息
Curr Opin Genet Dev. 2018 Feb;48:44-50. doi: 10.1016/j.gde.2017.10.007. Epub 2017 Nov 7.
Abstract
Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key tumor-suppressor mRNAs. In other cases, tumors adjust NMD activity to adapt to their microenvironment. Understanding how particular tumors exploit NMD for their benefit may augment the development of new therapeutic interventions.
摘要
无意义介导的 mRNA 降解（NMD）是一种保守的 mRNA 监控途径，细胞利用它来确保转录本的质量，并精细调节转录本的丰度。NMD 在癌症发展中的作用是复杂的。在某些情况下，肿瘤通过明显选择导致关键肿瘤抑制 mRNA 破坏的突变来利用 NMD 下调基因表达。在其他情况下，肿瘤调整 NMD 活性以适应其微环境。了解特定肿瘤如何利用 NMD 来获益，可能会增强新治疗干预措施的开发。
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