用于化学-光动力联合治疗的 pH 敏感介孔硅纳米粒子。

pH-Sensitive mesoporous silica nanoparticles for chemo-photodynamic combination therapy.

机构信息

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150010, China.

Food Science College, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

出版信息

Colloids Surf B Biointerfaces. 2018 Jan 1;161:442-448. doi: 10.1016/j.colsurfb.2017.11.006. Epub 2017 Nov 6.

DOI:10.1016/j.colsurfb.2017.11.006

PMID:29121617

Abstract

In order to optimize the chemotherapeutic efficacy of doxorubicin (DOX) and improve the photodynamic therapeutic effectiveness of rose bengal (RB), a mesoporous silica nanoparticle system was designed as the carrier of RB and DOX for chemo-photodynamic combination therapy. A pH-sensitive strategy has been exploited to enhance the delivery efficiency. Our results suggested that the production of singlet oxygen was independent of the release of RB while strongly influenced by the external DOX layer. This method showed several benefits, including accelerating cellular uptake of the payloads and enabling chemo-photodynamic combination therapy for synergistic cancer treatment. Our study provides a new way for co-delivery of chemotherapy agents and photosensitizers.

摘要

为了优化阿霉素（DOX）的化疗疗效，提高玫瑰红（RB）的光动力治疗效果，设计了一种介孔硅纳米粒子系统作为 RB 和 DOX 的载体，用于化疗-光动力联合治疗。利用 pH 敏感策略来提高递送效率。结果表明，单线态氧的产生与 RB 的释放无关，而与外部 DOX 层强烈相关。该方法具有一些优点，包括加速负载物的细胞摄取，并实现协同癌症治疗的化疗-光动力联合治疗。我们的研究为化疗药物和光敏剂的共递提供了一种新方法。