Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Rd. 600, Shanghai, 200233, People's Republic of China.
BMC Cancer. 2017 Nov 9;17(1):735. doi: 10.1186/s12885-017-3717-3.
Pregnancy is an unquantifiable risk to accelerate tumor growth of papillary thyroid carcinoma (PTC), and whether pregnancy induces an unfavorable prognosis of radioiodine refractory papillary thyroid carcinoma (RR-PTC) remains unknown.
We investigated the impact of pregnancy on the prognosis of pulmonary metastases in an RR-PTC woman via a long-term clinical follow-up and consecutive computed tomography examinations and serum tests. After a successful pregnancy, the metastatic lesions shrank with serum thyroglobulin slightly fluctuated under sustained thyroid stimulating hormone (TSH) suppression, demonstrating a favorable outcome.
This case study indicates that metastatic RR-PTC may not be aggravated by pregnancy under TSH suppression, and pregnancy should not be contraindicated in RR-PTC patients with stable disease.
妊娠是加速甲状腺乳头状癌（PTC）肿瘤生长的不可量化风险，妊娠是否会导致放射性碘难治性甲状腺乳头状癌（RR-PTC）预后不良尚不清楚。
我们通过长期临床随访和连续 CT 检查和血清检测，研究了妊娠对 RR-PTC 女性肺转移预后的影响。在成功妊娠后，转移病灶缩小，血清甲状腺球蛋白略有波动，TSH 持续抑制，提示预后良好。
本病例研究表明，在 TSH 抑制下，转移性 RR-PTC 可能不会因妊娠而加重，对于病情稳定的 RR-PTC 患者，妊娠不应被禁忌。
