Division of Vascular Surgery, University of New Mexico, Albuquerque, NM.
Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minn.
J Vasc Surg. 2018 Mar;67(3):713-721. doi: 10.1016/j.jvs.2017.07.134. Epub 2017 Nov 6.
The objective of this study was to compare outcomes after repair of type III and type IV thoracoabdominal aortic aneurysms (TAAAs) by three different open surgical techniques at a tertiary care institution.
Consecutive patients who underwent elective repair of type III and type IV TAAAs at our institution between 1999 and 2011 were retrospectively reviewed. Patients were divided into three groups according to surgical technique: clamp and sew (CS), left-sided heart bypass (LHB), and visceral branching (VB) followed by aortic reconstruction. Primary end points were early mortality and complications; secondary end points were need for blood transfusion, duration of operation, and long-term survival.
Between 1999 and 2011, there were 121 consecutive patients (83 men, 38 women) with 52 type III and 69 type IV TAAAs who underwent elective repair (CS, 65 patients; LHB, 31 patients; VB, 25 patients). Perioperative spinal drainage was used in 84%. Procedure duration was longest in the VB group (mean, 9.1 hours vs 7.7 hours and 5.7 hours for CS and LHB; P < .001), but transfusion requirement was largest in the LHB group (mean, 3.5 L vs 1.7 L and 2.1 L for CS and VB; P = .015). Mean duration of mesenteric ischemia was significantly shorter in the VB group vs CS and LHB (18 minutes vs 35 minutes for CS and 30 minutes for LHB; P < .0001). Mean intensive care unit and hospital stays were the same (9, 10, and 8 days [P = .82]; 18, 20, and 18 days [P = .76]). Overall 30-day mortality was 6.6%, not different between groups (6%, 10%, and 4%; P = .68). Mean follow-up was 45 ± 42 months, and actuarial overall survival at 3 and 5 years was 70% and 64%, with no difference between groups (P = .36).
For repair of type III and type IV TAAAs, the sequential VB technique has the longest duration, but it has the advantage of the shortest mesenteric and visceral ischemia times without improvement in early outcomes. Irrespective of the techniques used, complications, early mortality, risk of spinal cord injury, and survival were the same.
本研究旨在比较在一家三级医疗机构中,三种不同的开放性手术技术修复 III 型和 IV 型胸腹主动脉瘤(TAAA)的结果。
回顾性分析了 1999 年至 2011 年间我院连续行 III 型和 IV 型 TAAA 择期修复的患者。根据手术技术将患者分为三组:夹闭缝合(CS)、左心旁路(LHB)和内脏分支(VB)加主动脉重建。主要终点为早期死亡率和并发症;次要终点为输血需求、手术时间和长期生存。
1999 年至 2011 年间,连续有 121 例(83 例男性,38 例女性)患者接受了择期修复(CS 组 65 例,LHB 组 31 例,VB 组 25 例)。84%的患者使用了围手术期脊髓引流。VB 组的手术时间最长(平均 9.1 小时,CS 组和 LHB 组分别为 7.7 小时和 5.7 小时;P < 0.001),但 LHB 组的输血需求最大(平均 3.5 升,CS 组和 VB 组分别为 1.7 升和 2.1 升;P = 0.015)。VB 组肠系膜缺血的平均持续时间明显短于 CS 组和 LHB 组(CS 组 35 分钟,LHB 组 30 分钟,VB 组 18 分钟;P < 0.0001)。平均重症监护病房和住院时间相同(9、10 和 8 天[P = 0.82];18、20 和 18 天[P = 0.76])。30 天总体死亡率为 6.6%,各组间无差异(6%、10%和 4%;P = 0.68)。平均随访时间为 45 ± 42 个月,3 年和 5 年的总体生存率分别为 70%和 64%,各组间无差异(P = 0.36)。
对于 III 型和 IV 型 TAAA 的修复,序贯 VB 技术的手术时间最长,但肠系膜和内脏缺血时间最短,而早期结果无改善。无论使用何种技术,并发症、早期死亡率、脊髓损伤风险和生存率均相同。