Keefe R S, Mohs R C, Losonczy M F, Davidson M, Silverman J M, Horvath T B, Davis K L
Psychiatry Service, VA Medical Center, Bronx, NY 10468.
Am J Psychiatry. 1989 Feb;146(2):206-11. doi: 10.1176/ajp.146.2.206.
Chronic schizophrenic patients with the most severe social deterioration have been shown to differ from other chronic schizophrenic patients with respect to measures of left-to-right ventricular asymmetry, negative symptoms, and response to haloperidol treatment. In the current study, the authors investigated the social antecedents of these characteristics of very poor outcome schizophrenia in 69 chronic schizophrenic patients. Poor premorbid sociosexual functioning was associated with more severe left-to-right ventricular asymmetry, greater severity of negative symptoms, fewer positive symptoms, and worse current social functioning. These data suggest that factors associated with severe social deterioration in the end stage of schizophrenia are also associated with premorbid sociosexual impairment.
患有最严重社会功能衰退的慢性精神分裂症患者，在左右心室不对称测量、阴性症状以及对氟哌啶醇治疗的反应方面，已被证明与其他慢性精神分裂症患者存在差异。在当前研究中，作者调查了69例慢性精神分裂症患者中这些预后极差的精神分裂症特征的社会先兆。病前社会性功能差与更严重的左右心室不对称、更严重的阴性症状、更少的阳性症状以及更差的当前社会功能相关。这些数据表明，与精神分裂症末期严重社会功能衰退相关的因素，也与病前社会性功能损害有关。
