Addington J, Addington D
Department of Psychology, Holy Cross Hospital, Calgary, Alberta, Canada.
J Psychiatry Neurosci. 1993 Jan;18(1):18-23.
In this study we examined the relationship between premorbid functioning, outcome, cognitive functioning and positive and negative symptoms of schizophrenia. Cognitive functioning and symptoms were examined longitudinally in a sample of 39 subjects with schizophrenia (according to the DSM-III criteria). Subjects were assessed at admission to hospital and six months later during a period of relative remission. Premorbid functioning was significantly associated with negative symptoms but not with positive symptoms at both the acute phase and the remitted phase of the illness. Outcome was also associated with negative symptoms at admission and with both positive and negative symptoms at follow-up. Deficits on cognitive tests of verbal reasoning and concept formation were significantly associated with poor premorbid functioning and outcome.
在本研究中，我们考察了病前功能、治疗结果、认知功能与精神分裂症的阳性和阴性症状之间的关系。对39名符合《精神疾病诊断与统计手册第三版》（DSM-III）标准的精神分裂症患者样本进行了认知功能和症状的纵向研究。在患者入院时及六个月后处于相对缓解期时进行评估。病前功能在疾病的急性期和缓解期均与阴性症状显著相关，而与阳性症状无关。治疗结果在入院时与阴性症状相关，在随访时与阳性和阴性症状均相关。言语推理和概念形成的认知测试缺陷与不良的病前功能及治疗结果显著相关。
