Chen Xinglong, Zhang Xiuqiong, Geng Changan, Li Tianze, Chen Jijun
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, PR China.
Fitoterapia. 2018 Jan;124:160-166. doi: 10.1016/j.fitote.2017.11.005. Epub 2017 Nov 6.
Four new C-noriridals (1-4) and two reported C-noriridals (5-6), together with two new formyl-monocycloiridals (7-8) and three known monocycloiridals (9-11) were isolated from the rhizomes of Iris pseudoacorus. Irispseudoacorins A-D (1-4) and iridojaponals A-B (5-6) were C-noriridals which shared a 6/5/7 tricyclic ring system (1-2, 5-6) or 6/5 tricyclic ring system (3-4). The formyl-monocycloiridals (7-8) were detected in the crude extracts of I. pseudoacorus by LC-MS analysis which suggested they were originated from natural sources rather than artificial products during the isolation. Their structures were determined by UV, IR, extensive NMR spectra and X-ray diffraction analyses. The known monocycloiridals 9-10 displayed pronounced cytotoxic effects against five human tumor cell lines. The IC values of 9 were ranging from 12.63 to 24.69μM.
从黄菖蒲的根茎中分离出了4个新的C-降环烯醚萜（1-4）和2个已报道的C-降环烯醚萜（5-6），以及2个新的甲酰基单环烯醚萜（7-8）和3个已知的单环烯醚萜（9-11）。鸢尾假菖蒲素A-D（1-4）和虹彩日本酮A-B（5-6）是C-降环烯醚萜，它们具有6/5/7三环体系（1-2，5-6）或6/5三环体系（3-4）。通过液相色谱-质谱分析在黄菖蒲的粗提物中检测到了甲酰基单环烯醚萜（7-8），这表明它们是在分离过程中源自天然来源而非人工产物。它们的结构通过紫外、红外、广泛的核磁共振光谱和X射线衍射分析确定。已知的单环烯醚萜9-10对5种人类肿瘤细胞系显示出明显的细胞毒性作用。9的半数抑制浓度值范围为12.63至24.69μM。
