从肾蕨根茎中分离得到的一个新的齿叶土沉香型三萜。
A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.
机构信息
School of Pharmaceutical Sciences, Peking University, Beijing, PR China.
出版信息
Fitoterapia. 2010 Dec;81(8):988-91. doi: 10.1016/j.fitote.2010.06.013. Epub 2010 Jun 21.
Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively.
金粟兰酮（1），一种罕见的新型金粟兰烷型三萜，与五种已知的三萜类化合物一起从肾蕨（Kunze）J. Sm 的根茎中分离得到。根据广泛的 1D 和 2D NMR 以及 MS 光谱分析，结构被表征为 20β-羟基金粟兰烷-22-酮，并通过 X 射线晶体衍射进一步证实。初步生物测定表明，化合物 1 对 Hela、PC3 和 HepG2 细胞具有显著的细胞毒性活性，IC50 分别为 2.92 μM、1.08 μM 和 2.45 μM。
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