Mercadante M T, Busatto G F, Lombroso P J, Prado L, Rosário-Campos M C, do Valle R, Marques-Dias M J, Kiss M H, Leckman J F, Miguel E C
Department of Psychiatry, Medical School, University of São Paulo, Brazil.
Am J Psychiatry. 2000 Dec;157(12):2036-8. doi: 10.1176/appi.ajp.157.12.2036.
This study examined the frequency and age at onset of psychiatric disorders among children with rheumatic fever, Sydenham's chorea, or both and a comparison group.
Twenty children with rheumatic fever, 22 with Sydenham's chorea, and 20 comparison children were assessed by means of a semistructured interview and rating scales for tic disorders and obsessive-compulsive disorder.
Obsessive-compulsive symptoms were more frequent in both the Sydenham's chorea and rheumatic fever groups than in the comparison group. The Sydenham's chorea group had a higher frequency of major depressive disorder, tic disorders, and attention deficit hyperactivity disorder (ADHD) than both the comparison and rheumatic fever groups. ADHD symptoms were associated with a higher risk of developing Sydenham's chorea.
Both the rheumatic fever and Sydenham's chorea groups were associated with a higher risk of developing neuropsychiatric disorders than the comparison group. ADHD appears to be a risk factor for Sydenham's chorea in children with rheumatic fever.
本研究调查了患有风湿热、小舞蹈病或两者兼具的儿童以及一个对照组儿童精神障碍的发病频率和发病年龄。
通过半结构化访谈以及抽动障碍和强迫症评定量表，对20名患有风湿热的儿童、22名患有小舞蹈病的儿童和20名对照儿童进行评估。
小舞蹈病组和风湿热组的强迫症状均比对照组更为常见。小舞蹈病组的重度抑郁症、抽动障碍和注意力缺陷多动障碍（ADHD）的发病率高于对照组和风湿热组。ADHD症状与患小舞蹈病的较高风险相关。
与对照组相比，风湿热组和小舞蹈病组发生神经精神障碍的风险更高。ADHD似乎是患有风湿热儿童患小舞蹈病的一个风险因素。
