Kumar Vidhya, Hsueh Willa A, Raman Subha V
From the Ohio State University Davis Heart and Lung Research Institute, Columbus (V.K., W.A.H., S.V.R.); and Division of Endocrinology, Diabetes & Metabolism, Ohio State University, Columbus (W.A.H.).
Circ Cardiovasc Imaging. 2017 Nov;10(11). doi: 10.1161/CIRCIMAGING.117.005447.
Cardiometabolic disease, spanning conditions such as obesity to type 2 diabetes mellitus with excess cardiovascular risk, represents a major public health burden. Advances in preclinical translational science point to potential targets across multiple organ systems for early intervention to improve cardiometabolic health. Validation in clinical trials and translation to care would benefit from in vivo diagnostic techniques that facilitate therapeutic advancements. This review provides a state-of-the-art, multimodality perspective spanning the multiple organ systems that contribute to cardiometabolic disease.
心血管代谢疾病涵盖从肥胖到伴有心血管风险增加的2型糖尿病等多种病症，是一项重大的公共卫生负担。临床前转化科学的进展指出了多个器官系统中的潜在靶点，可用于早期干预以改善心血管代谢健康。临床试验中的验证以及转化为临床治疗将受益于有助于治疗进展的体内诊断技术。本综述提供了一个涵盖导致心血管代谢疾病的多个器官系统的最新多模态视角。
