骨骼肌和肝脏的活体磷磁共振波谱分析：一种非侵入性评估其代谢的方法。

In-vivoP-MRS of skeletal muscle and liver: A way for non-invasive assessment of their metabolism.

作者信息

Valkovič Ladislav, Chmelík Marek, Krššák Martin

机构信息

High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom; Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia.

High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria; Institute for Clinical Molecular MRI in Musculoskeletal System, Karl Landsteiner Society, Vienna, Austria.

出版信息

Anal Biochem. 2017 Jul 15;529:193-215. doi: 10.1016/j.ab.2017.01.018. Epub 2017 Jan 21.

In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (P-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vivo. Even though the great potential of P-MR was recognized over 30 years ago, modern MR systems, as well as new, dedicated hardware and measurement techniques provide further opportunities for research of human biochemistry. This paper presents a methodological overview of the P-MR techniques that can be used for basic, physiological, or clinical research of human skeletal muscle and liver in vivo. Practical issues of P-MRS experiments and examples of potential applications are also provided. As signal localization is essential for liver P-MRS and is important for dynamic muscle examinations as well, typical localization strategies for P-MR are also described.