Department of Pneumology and Allergy, 1st Chair of Internal Medicine.
Healthy Aging Research Centre.
Clin Interv Aging. 2017 Oct 24;12:1811-1817. doi: 10.2147/CIA.S142483. eCollection 2017.
Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Therefore, the aim of our review was to describe and discuss some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy.
虽然目前治疗慢性阻塞性肺疾病（COPD）的方法可以提高生活质量，但它们并不能令人满意地减缓疾病进展或降低死亡率。对于导致该疾病病理生物学的细胞、分子和遗传机制，我们的了解仍然存在许多空白。然而，越来越多的证据表明，加速衰老、慢性全身炎症和氧化应激在 COPD 的发病机制中起主要作用，从而为治疗提供了新的机会。因此，我们的综述旨在描述和讨论一些最广泛使用的治疗方法，这些方法可以影响衰老和氧化应激的根本原因（二甲双胍、褪黑素、西罗莫司、他汀类药物、维生素 D 和睾酮）在 COPD 治疗中的作用。
