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通过互联网获取的西布曲明导致心脏骤停:一名无心血管疾病史的年轻女性病例经体外膜肺氧合成功复苏。

Cardiac arrest caused by sibutramine obtained over the Internet: a case of a young woman without pre-existing cardiovascular disease successfully resuscitated using extracorporeal membrane oxygenation.

作者信息

Bunya Naofumi, Sawamoto Keigo, Uemura Shuji, Kyan Ryoko, Inoue Hiroyuki, Nishida Junichi, Kouzu Hidemichi, Kokubu Nobuaki, Miura Tetsuji, Narimatsu Eichi

机构信息

Department of Emergency Medicine Sapporo Medical University Hokkaido Japan.

Department of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University Hokkaido Japan.

出版信息

Acute Med Surg. 2017 Mar 29;4(3):334-337. doi: 10.1002/ams2.275. eCollection 2017 Jul.

Abstract

CASE

Sibutramine is a weight loss agent that was withdrawn from the market in the USA and European Union because it increases adverse events in patients with cardiovascular diseases. However, non-prescription weight loss pills containing sibutramine can be still easily purchased over the Internet.

UNLABELLED

A 21-year-old woman without history of cardiovascular diseases developed cardiac arrest. She was a user of a weight loss pills, containing sibutramine and hypokalemia-inducing agents, imported from Thailand over the Internet.

OUTCOME

She was successfully resuscitated without any neurological deficits by using extracorporeal membrane oxygenation for refractory ventricular fibrillation.

CONCLUSION

This case indicates that sibutramine can cause cardiac arrest even in subjects without pre-existing cardiovascular disease when combined with agents that promote QT prolongation.

摘要

病例

西布曲明是一种减肥药物,因会增加心血管疾病患者的不良事件而在美国和欧盟退市。然而,含有西布曲明的非处方减肥药仍可轻易在互联网上购得。

未标注

一名无心血管疾病史的21岁女性发生心脏骤停。她使用了通过互联网从泰国进口的一种含有西布曲明和致低钾血症药物的减肥药。

结果

通过体外膜肺氧合治疗难治性室颤,她成功复苏且无任何神经功能缺损。

结论

该病例表明,西布曲明与促进QT间期延长的药物合用时,即使在无心血管疾病史的个体中也可导致心脏骤停。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d3/5674461/596828389861/AMS2-4-334-g001.jpg

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