Iseme Rosebella A, Mcevoy Mark, Kelly Brian, Agnew Linda, Walker Frederick R, Attia John
Department of Population and Reproductive Health, School of Public Health, Kenyatta University, P.O. Box 43844 -, 00100, Nairobi, Kenya.
School of Medicine & Public Health, The University of Newcastle, Callaghan, NSW, 2308, Australia.
Bone Rep. 2017 Oct 16;7:121-131. doi: 10.1016/j.bonr.2017.10.003. eCollection 2017 Dec.
The last two decades have marked a growing understanding of the interaction occurring between bone and immune cells. The chronic inflammation and immune system dysfunction commonly observed to occur during the ageing process and as part of a range of other pathological conditions, commonly associated with osteoporosis has led to the recognition of these processes as important determinants of bone disease. This is further supported by the recognition that the immune and bone systems in fact share regulatory mechanisms and progenitor molecules. Research into this complex synergy has provided a better understanding of the immunopathogenesis underlying bone diseases such as osteoporosis. However, existing research has largely focussed on delineating the role played by inflammation in pathogenic bone destruction, despite increasing evidence implicating autoantibodies as important drivers of osteoporosis. This review shall attempt to provide a comprehensive overview of existing research examining the role played by autoantibodies in osteoporosis in order to determine the potential for further research in this area. Autoantibodies represent promising targets for the improved treatment and diagnosis of inflammatory bone loss.
在过去二十年里，人们对骨骼与免疫细胞之间的相互作用有了越来越深入的了解。在衰老过程中以及一系列其他病理状况（通常与骨质疏松症相关）中普遍观察到的慢性炎症和免疫系统功能障碍，已使人们认识到这些过程是骨病的重要决定因素。免疫系统和骨骼系统实际上共享调节机制和祖细胞分子这一认识进一步支持了这一点。对这种复杂协同作用的研究，使人们对骨质疏松症等骨病的免疫发病机制有了更好的理解。然而，尽管越来越多的证据表明自身抗体是骨质疏松症的重要驱动因素，但现有研究主要集中在阐明炎症在致病性骨破坏中所起的作用。本综述将试图全面概述现有研究，探讨自身抗体在骨质疏松症中所起的作用，以确定该领域进一步研究的潜力。自身抗体是改善炎症性骨质流失治疗和诊断的有前景的靶点。
