Chen Yong, Chen Fu-Hua, Chen Yi-Qing, Zhang Qiu
Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Nutr. 2022 Aug 9;9:891995. doi: 10.3389/fnut.2022.891995. eCollection 2022.
The aim of this study was to study the relationship between modified dietary inflammatory index (MDII) score with osteoporosis (OP) in adult Americans.
Data were extracted from the United States National Health and Nutrition Examination Survey (NHANES) (2007-2008, 2009-2010, 2013-2014, and 2017-2018). In this cross-sectional study, 5,446 participants were included and analyzed. Potential dietary inflammatory was assessed by MDII score (24-h recall), a composite method computed according to the relationship between nutrients and systemic pro-inflammatory cytokine level, and was further classified into tertiles. Weighted multivariable logistic regression analysis was employed to examine the associations between OP and MDII scores.
In weighted multivariable-adjusted logistic regression models, the highest tertile of MDII score was associated with an increased risk of OP [odds ratio (OR): 1.73, 95% confidence interval (95 CI%): 1.14-2.63]. In participants aged above 59 years, a higher MDII score showed a higher risk of OP (OR: 1.92; 95 CI%: 1.16-3.15). In the sex-stratified models, the results remained significant only among women (OR: 1.80; 95% CI: 1.02-3.17). In the menopausal status stratified model, after adjusting potential confounding variables, the association between the MDII score, either as a categorical (OR: 1.88; 95% CI: 1.07-3.13) or continuous variables (OR: 1.19; 95%CI: 1.02-1.38), and OP risk was significant among postmenopausal women.
Our study indicates that a higher MDII score (pro-inflammatory effect) is significantly associated with an increased risk of OP in US adults, especially among those postmenopausal women more than 60 years. This study further supports that those dietary changes have the potential to prevent OP.
本研究旨在探讨美国成年人中改良饮食炎症指数（MDII）得分与骨质疏松症（OP）之间的关系。
数据来自美国国家健康与营养检查调查（NHANES）（2007 - 2008年、2009 - 2010年、2013 - 2014年和2017 - 2018年）。在这项横断面研究中，纳入并分析了5446名参与者。通过MDII得分（24小时回忆法）评估潜在的饮食炎症，MDII得分是一种根据营养素与全身促炎细胞因子水平之间的关系计算得出的综合方法，并进一步分为三分位数。采用加权多变量逻辑回归分析来检验OP与MDII得分之间的关联。
在加权多变量调整逻辑回归模型中，MDII得分的最高三分位数与OP风险增加相关[比值比（OR）：1.73，95%置信区间（95CI%）：1.14 - 2.63]。在年龄大于59岁的参与者中，较高的MDII得分显示出较高的OP风险（OR：1.92；95CI%：1.16 - 3.15）。在按性别分层的模型中，结果仅在女性中仍然显著（OR：1.80；95%CI：1.02 - 3.17）。在绝经状态分层模型中，在调整潜在混杂变量后，MDII得分作为分类变量（OR：1.88；95%CI：1.07 - 3.13）或连续变量（OR：1.19；95%CI：1.02 - 1.38）与绝经后女性的OP风险之间的关联是显著的。
我们的研究表明，较高的MDII得分（促炎作用）与美国成年人中OP风险增加显著相关，尤其是在60岁以上的绝经后女性中。本研究进一步支持饮食改变有可能预防OP。
