Bush Terry, Lovejoy Jennifer, Javitz Harold, Mahuna Stacey, Torres Alula Jimenez, Wassum Ken, Magnusson Brooke, Benedict Cody, Spring Bonnie
Alere Wellbeing, solely owned subsidiary of Optum, 999 Third Avenue Suite 1800, Seattle, Washington 98104-1139, USA.
Arivale, Inc and University of Washington School of Public Health, Seattle, WA.
Contemp Clin Trials Commun. 2017 Sep;7:95-102. doi: 10.1016/j.conctc.2017.06.003. Epub 2017 Jun 15.
Two-thirds of treatment-seeking smokers are obese or overweight. Most smokers are concerned about gaining weight after quitting. The average smoker experiences modest post-quit weight gain which discourages many smokers from quitting. Although evidence suggests that combined interventions to help smokers quit smoking and prevent weight gain can be helpful, studies have not been replicated in real world settings.
This paper describes recruitment and participant characteristics of the Best Quit Study, a 3-arm randomized controlled trial testing tobacco cessation treatment alone or combined with simultaneous or sequential weight management. Study participants were recruited via tobacco quitlines from August 5, 2013 to December 15, 2014.
Statistical analysis on baseline data was conducted in 2015/2016. Among 5,082 potentially eligible callers to a tobacco quitline, 2,540 were randomized (50% of eligible). Compared with individuals eligible but not randomized, those randomized were significantly more likely to be female (65.7% vs 54.5%, p<.01), overweight or obese (76.3% vs 62.5%, p<.01), more confident in quitting (p<.01), more addicted (first cigarette within 5 minutes: 50.0% vs 44.4%, p<.01), and have a chronic disease (28.6% vs. 24.4%, p<.01). Randomized groups were not statistically significantly different on demographics, tobacco or weight variables. Two-thirds of participants were female and white with a mean age of 43.
Adding weight management interventions to tobacco cessation quitlines was feasible and acceptable to smokers. If successful for cessation and weight outcomes, a combined intervention may provide a treatment approach for addressing weight gain with smoking cessation through tobacco quitlines.
寻求治疗的吸烟者中有三分之二肥胖或超重。大多数吸烟者担心戒烟后体重增加。吸烟者平均在戒烟后体重会适度增加，这使许多吸烟者不愿戒烟。尽管有证据表明，帮助吸烟者戒烟并防止体重增加的联合干预措施可能会有帮助，但相关研究尚未在现实环境中得到重复验证。
本文描述了“最佳戒烟研究”的招募情况和参与者特征，这是一项三臂随机对照试验，测试单独的戒烟治疗或与同时或相继的体重管理相结合的治疗。研究参与者于2013年8月5日至2014年12月15日通过戒烟热线招募。
2015/2016年对基线数据进行了统计分析。在拨打戒烟热线的5082名潜在合格者中，2540人被随机分组（占合格者的50%）。与符合条件但未被随机分组的个体相比，被随机分组的个体更有可能是女性（65.7%对54.5%，p<0.01）、超重或肥胖（76.3%对62.5%，p<0.01）、对戒烟更有信心（p<0.01）、烟瘾更大（在5分钟内吸第一支烟：50.0%对44.4%，p<0.01），并且患有慢性病（28.6%对24.4%，p<0.01）。随机分组在人口统计学、烟草或体重变量方面没有统计学上的显著差异。三分之二的参与者是女性且为白人，平均年龄为43岁。
在戒烟热线中增加体重管理干预措施对吸烟者来说是可行且可接受的。如果在戒烟和体重方面取得成功，联合干预可能会提供一种通过戒烟热线解决戒烟后体重增加问题的治疗方法。
