Discipline of Social Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia.
Heart Fail Rev. 2018 Jan;23(1):131-145. doi: 10.1007/s10741-017-9661-0.
The aim of this study is to perform a systematic review of the costing methodological approaches adopted by published cost-of-illness (COI) studies. A systematic review was performed to identify cost-of-illness studies of heart failure published between January 2003 and September 2015 via computerized databases such as Pubmed, Wiley Online, Science Direct, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Costs reported in the original studies were converted to 2014 international dollars (Int$). Thirty five out of 4972 studies met the inclusion criteria. Nineteen out of the 35 studies reported the costs as annual cost per patient, ranging from Int$ 908.00 to Int$ 84,434.00, while nine studies reported costs as per hospitalization, ranging from Int$ 3780.00 to Int$ 34,233.00. Cost of heart failure increased as condition of heart failure worsened from New York Heart Association (NYHA) class I to NYHA class IV. Hospitalization cost was found to be the main cost driver to the total health care cost. The annual cost of heart failure ranges from Int$ 908 to Int$ 40,971 per patient. The reported cost estimates were inconsistent across the COI studies, mainly due to the variation in term of methodological approaches such as disease definition, epidemiological approach of study, study perspective, cost disaggregation, estimation of resource utilization, valuation of unit cost components, and data sources used. Such variation will affect the reliability, consistency, validity, and relevance of the cost estimates across studies.
本研究旨在对已发表的疾病经济负担（COI）研究中采用的成本核算方法进行系统回顾。通过计算机检索 Pubmed、Wiley Online、Science Direct、Web of Science 和 Cumulative Index to Nursing and Allied Health Literature（CINAHL）等数据库，检索 2003 年 1 月至 2015 年 9 月间发表的心力衰竭 COI 研究，采用系统评价方法进行文献筛选，纳入符合标准的心力衰竭疾病经济负担研究。原始研究报告的成本均转换为 2014 年国际元（Int$）。共纳入 35 项研究，其中 19 项研究报告了心力衰竭患者的年度人均成本，范围为 Int$ 908.00 至 Int$ 84,434.00，9 项研究报告了心力衰竭患者的住院费用，范围为 Int$ 3780.00 至 Int$ 34,233.00。随着心力衰竭严重程度从纽约心脏病协会（NYHA）心功能 I 级到 NYHA 心功能 IV 级，心力衰竭的成本逐渐增加。心力衰竭的住院费用是导致总医疗费用的主要因素。心力衰竭患者的年人均医疗费用为 Int$ 908 至 Int$ 40,971。由于疾病定义、研究的流行病学方法、研究视角、成本分解、资源利用评估、单位成本组成部分的估值以及使用的数据来源等方法学上的差异，COI 研究中的成本估计值不一致。这种差异将影响研究间成本估计值的可靠性、一致性、有效性和相关性。
