França Katlein, Lotti Torello M
Centro Studi per la Ricerca Multidisciplinare e Rigenerativa, Universita Degli Studi "G. Marconi", Rome, Italy.
Institute for Bioethics & Health Policy; Department of Dermatology & Cutaneous Surgery; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Adv Exp Med Biol. 2017;996:123-134. doi: 10.1007/978-3-319-56017-5_11.
Psycho-Neuro-Endocrine-Immunology (P.N.E.I.) is a scientific field of study that investigates the link between bidirectional communications among the nervous system, the endocrine system, and the immune system and the correlations of this cross-talk with physical health. The P.N.E.I. innovative medical approach represents a paradigm shift from a strictly biomedical view of health and disease taken as hermetically sealed compartments to a more interdisciplinary one. The key element of P.N.E.I. approach is represented by the concept of bidirectional cross-talk between the psychoneuroendocrine and immune systems. The Low Dose Medicine is one of the most promising approaches able to allow the researchers to design innovative therapeutic strategies for the treatment of skin diseases based on the rebalance of the immune response.
心理神经内分泌免疫学（P.N.E.I.）是一个科学研究领域，它研究神经系统、内分泌系统和免疫系统之间双向通信的联系，以及这种相互作用与身体健康的相关性。P.N.E.I.创新医学方法代表了一种范式转变，从将健康和疾病视为完全封闭的隔室的严格生物医学观点，转变为更具跨学科性的观点。P.N.E.I.方法的关键要素由心理神经内分泌系统和免疫系统之间双向相互作用的概念所代表。低剂量医学是最有前景的方法之一，能够让研究人员基于免疫反应的重新平衡，设计出治疗皮肤病的创新治疗策略。
