WU Lien-Teh Institute, Department of Microbiology, Harbin Medical University, Harbin, China.
Department of Experimental Tuberculosis, St. Petersburg State Research Institute of Phthisiopulmonology, Saint-Petersburg, Russia.
Front Endocrinol (Lausanne). 2023 Sep 29;14:1120475. doi: 10.3389/fendo.2023.1120475. eCollection 2023.
With the global epidemic and prevention of the COVID-19, long COVID-19 sequelae and its comprehensive prevention have attracted widespread attention. Long COVID-19 sequelae refer to that three months after acute COVID-19, the test of SARS-CoV-2 is negative, but some symptoms still exist, such as cough, prolonged dyspnea and fatigue, shortness of breath, palpitations and insomnia. Its pathological mechanism is related to direct viral damage, immunopathological response, endocrine and metabolism disorders. Although there are more effective methods for treating COVID-19, the treatment options available for patients with long COVID-19 remain quite limited. Psychophysical therapies, such as exercise, oxygen therapy, photobiomodulation, and meditation, have been attempted as treatment modalities for long COVID-19, which have the potential to promote recovery through immune regulation, antioxidant effects, and neuroendocrine regulation. Neuroendocrine regulation plays a significant role in repairing damage after viral infection, regulating immune homeostasis, and improving metabolic activity in patients with long COVID-19. This review uses oxytocin as an example to examine the neuroendocrine mechanisms involved in the psychophysical therapies of long COVID-19 syndrome and proposes a psychophysical strategy for the treatment of long COVID-19.
随着全球疫情和 COVID-19 的预防，长新冠后遗症及其综合防治受到广泛关注。长新冠后遗症是指急性 COVID-19 三个月后，SARS-CoV-2 检测呈阴性，但仍存在一些症状，如咳嗽、呼吸困难和疲劳持续时间延长、呼吸急促、心悸和失眠等。其病理机制与直接病毒损伤、免疫病理反应、内分泌和代谢紊乱有关。尽管 COVID-19 的治疗方法更加有效，但长新冠患者的治疗选择仍然相当有限。心理生理疗法，如运动、氧疗、光生物调节和冥想，已被尝试作为长新冠的治疗方法，这些方法有可能通过免疫调节、抗氧化作用和神经内分泌调节促进康复。神经内分泌调节在修复病毒感染后的损伤、调节免疫稳态以及改善长新冠患者的代谢活性方面发挥着重要作用。本综述以催产素为例，探讨了长新冠综合征心理生理疗法的神经内分泌机制，并提出了一种长新冠的心理生理治疗策略。
