Douros Konstantinos, Boutopoulou Barbara, Fouzas Sotirios, Loukou Ioanna
3rd Department of Paediatrics, "Attikon" Hospital, University of Athens School of Medicine, Athens, Greece.
Department of Paediatrics, School of Medicine, University of Patras, Patras, Greece.
Adv Exp Med Biol. 2017;996:169-183. doi: 10.1007/978-3-319-56017-5_14.
The increase in asthma and allergies prevalence that has been recorded in many countries during the last decades, and the reemergence of vitamin D (VD) deficiency in many populations worldwide, renders fairly plausible the assumption of an underlying association between these two conditions and justifies the research effort invented in this issue. Indeed, there is growing body of evidence from epidemiological, laboratory, and clinical studies, suggesting that such an association does exist. The hypothesis of low levels of VD leading to compromised fetal programming and impairment of various immune functions involved in asthma and allergic disorders, stands as the most credible explanation of this presumed association. However, the evidence is not yet definite and there are some conflicting results among studies. As a consequence, no safe conclusions can be drawn yet, and more research is required in order to fully clarify the involvement of VD deficiency in the pathogenesis of asthma and allergies, and decide if VD has a role to play in the prevention and therapy of these disorders.
在过去几十年中，许多国家都记录到哮喘和过敏症患病率有所上升，且全球许多人群中维生素D（VD）缺乏症再度出现，这使得人们相当有理由假定这两种情况之间存在潜在关联，并证明了针对此问题展开研究工作的合理性。的确，来自流行病学、实验室和临床研究的证据越来越多，表明这种关联确实存在。VD水平低会导致胎儿发育编程受损以及参与哮喘和过敏性疾病的各种免疫功能受损这一假说，是对这种假定关联最可信的解释。然而，证据尚不确凿，研究中存在一些相互矛盾的结果。因此，目前还无法得出可靠结论，需要更多研究来全面阐明VD缺乏在哮喘和过敏症发病机制中的作用，并确定VD在这些疾病的预防和治疗中是否能发挥作用。
