Zhao Xiaoman, Hu Mingge, Zhou Huan, Yang Yan, Shen Shiping, You Yannan, Xue Zheng
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Microbiol. 2023 Jul 27;14:1219942. doi: 10.3389/fmicb.2023.1219942. eCollection 2023.
Asthma is one of the common chronic respiratory diseases in children, which poses a serious threat to children's quality of life. Respiratory infection is a risk factor for asthma. Compared with healthy children, children with early respiratory infections have a higher risk of asthma and an increased chance of developing severe asthma. Many clinical studies have confirmed the correlation between respiratory infections and the pathogenesis of asthma, but the underlying mechanism is still unclear. The gut microbiome is an important part of maintaining the body's immune homeostasis. The imbalance of the gut microbiome can affect the lung immune function, and then affect lung health and cause respiratory diseases. A large number of evidence supports that there is a bidirectional regulation between intestinal flora and respiratory tract infection, and both are significantly related to the development of asthma. The changes of intestinal microbial components and their metabolites in respiratory tract infection may affect the occurrence and development of asthma through the immune pathway. By summarizing the latest advancements in research, this review aims to elucidate the intricate connection between respiratory tract infections and the progression of asthma by highlighting its bridging role of the gut microbiome. Furthermore, it offers novel perspectives and ideas for future investigations into the mechanisms that underlie the relationship between respiratory tract infections and asthma.
哮喘是儿童常见的慢性呼吸道疾病之一，对儿童的生活质量构成严重威胁。呼吸道感染是哮喘的一个危险因素。与健康儿童相比，早期呼吸道感染的儿童患哮喘的风险更高，且发展为重度哮喘的几率增加。许多临床研究证实了呼吸道感染与哮喘发病机制之间的相关性，但其潜在机制仍不清楚。肠道微生物群是维持机体免疫稳态的重要组成部分。肠道微生物群的失衡会影响肺部免疫功能，进而影响肺部健康并引发呼吸道疾病。大量证据支持肠道菌群与呼吸道感染之间存在双向调节，且二者均与哮喘的发生发展密切相关。呼吸道感染时肠道微生物成分及其代谢产物的变化可能通过免疫途径影响哮喘的发生发展。通过总结最新研究进展，本综述旨在通过强调肠道微生物群的桥梁作用来阐明呼吸道感染与哮喘进展之间的复杂联系。此外，它为未来研究呼吸道感染与哮喘之间关系的潜在机制提供了新的视角和思路。
