Veterans Affairs Eastern Colorado Healthcare System, Denver, and University of Colorado School of Medicine, Aurora.
Veterans Affairs Medical Center, Durham, North Carolina.
Arthritis Care Res (Hoboken). 2018 Aug;70(8):1141-1149. doi: 10.1002/acr.23466. Epub 2018 Jul 5.
To identify patient demographic and clinical characteristics associated with osteoarthritis (OA) treatment use.
This was a secondary data analysis of 3 clinical trials among patients with hip or knee OA conducted in Duke Primary Care practices, the Durham Veterans Affairs (VA) Health Care System, and the University of North Carolina-Chapel Hill (UNC). At baseline, participants reported sociodemographic characteristics, OA-related pain and function, and OA treatment use, including oral analgesics, topical creams, joint injections, and physical therapy. Separate, multivariable logistic models (adjusted for clustering of clinics and providers for the Duke and VA cohorts) were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations between participant characteristics and each type of OA treatment.
Oral analgesic use was reported by 70-82% of participants across the 3 cohorts. Physical therapy, knee injections, and topical creams were used by 39-52%, 55-60%, and 25-39% of Duke, VA, and UNC participants, respectively. In multivariable models, worse pain, stiffness, and function, per 5-unit increase, were associated with greater odds of using any oral analgesic for the cohorts from Duke (OR 1.18 [95% CI 1.08-1.28]) and UNC (OR 1.14 [95% CI 1.05-1.24]), but not for the VA cohort (OR 1.04 [95% CI 0.95-1.14]). For all 3 cohorts, nonwhites had higher odds of using topical creams compared to whites.
Results suggest potential underutilization of therapies other than oral analgesics. Patient characteristics may affect OA treatment use, and understanding the relationship between these factors and OA treatment preferences may improve adherence to OA treatment guidelines.
确定与骨关节炎(OA)治疗使用相关的患者人口统计学和临床特征。
这是对在杜克初级保健诊所、达勒姆退伍军人事务部(VA)医疗保健系统和北卡罗来纳大学教堂山分校(UNC)进行的 3 项髋关节或膝关节 OA 患者临床试验的二次数据分析。在基线时,参与者报告了社会人口统计学特征、OA 相关疼痛和功能以及 OA 治疗使用情况,包括口服镇痛药、局部乳膏、关节内注射和物理治疗。使用单独的多变量逻辑模型(针对杜克和 VA 队列的诊所和提供者聚类进行调整),估计参与者特征与每种 OA 治疗之间的关联的优势比(OR)和 95%置信区间(95%CI)。
在 3 个队列中,有 70-82%的参与者报告使用了口服镇痛药。物理治疗、膝关节注射和局部乳膏在杜克、VA 和 UNC 参与者中分别使用了 39-52%、55-60%和 25-39%。在多变量模型中,与杜克(OR 1.18 [95%CI 1.08-1.28])和 UNC 队列(OR 1.14 [95%CI 1.05-1.24])相比,每增加 5 个单位的疼痛、僵硬和功能恶化与使用任何口服镇痛药的几率增加相关,但与 VA 队列无关(OR 1.04 [95%CI 0.95-1.14])。对于所有 3 个队列,与白人相比,非白人使用局部乳膏的几率更高。
结果表明,除口服镇痛药外,其他疗法的潜在利用率较低。患者特征可能会影响 OA 治疗的使用,了解这些因素与 OA 治疗偏好之间的关系可能会提高 OA 治疗指南的依从性。