INSERM, UMR1090 TAGC, Marseille F-13288, France.
Aix-Marseille Université, UMR1090 TAGC, Marseille F-13288, France.
Nucleic Acids Res. 2018 Jan 4;46(D1):D267-D275. doi: 10.1093/nar/gkx1092.
With this latest release of ReMap (http://remap.cisreg.eu), we present a unique collection of regulatory regions in human, as a result of a large-scale integrative analysis of ChIP-seq experiments for hundreds of transcriptional regulators (TRs) such as transcription factors, transcriptional co-activators and chromatin regulators. In 2015, we introduced the ReMap database to capture the genome regulatory space by integrating public ChIP-seq datasets, covering 237 TRs across 13 million (M) peaks. In this release, we have extended this catalog to constitute a unique collection of regulatory regions. Specifically, we have collected, analyzed and retained after quality control a total of 2829 ChIP-seq datasets available from public sources, covering a total of 485 TRs with a catalog of 80M peaks. Additionally, the updated database includes new search features for TR names as well as aliases, including cell line names and the ability to navigate the data directly within genome browsers via public track hubs. Finally, full access to this catalog is available online together with a TR binding enrichment analysis tool. ReMap 2018 provides a significant update of the ReMap database, providing an in depth view of the complexity of the regulatory landscape in human.
随着 ReMap（http://remap.cisreg.eu）的最新发布，我们呈现了一个独特的人类调控区域集合，这是对数百个转录调控因子（TRs）的大规模综合分析的结果，如转录因子、转录共激活因子和染色质调控因子。在 2015 年，我们引入了 ReMap 数据库，通过整合公共 ChIP-seq 数据集来捕获基因组调控空间，涵盖了 237 个 TRs 的 1300 万个（M）峰。在这个版本中，我们扩展了这个目录，构成了一个独特的调控区域集合。具体来说，我们收集、分析和质量控制后保留了总计 2829 个来自公共来源的 ChIP-seq 数据集，涵盖了总共 485 个 TRs 和一个 80M 峰的目录。此外，更新后的数据库包括新的 TR 名称和别名搜索功能，包括细胞系名称，并能够通过公共跟踪集线器直接在基因组浏览器中导航数据。最后，这个目录的完整访问权限可以在线获得，同时还提供了一个 TR 结合富集分析工具。ReMap 2018 为 ReMap 数据库提供了一个重大更新，深入展示了人类调控景观的复杂性。
