Schmitt C, Brachmann J, Schöls W, Beyer T, Kübler W
Abteilung Innere Medizin III, Medizinische Universitätsklinik Heidelberg.
Dtsch Med Wochenschr. 1989 Jan 20;114(3):99-102. doi: 10.1055/s-2008-1066560.
A 23-year-old woman was hospitalized because of life-threatening monomorphic ventricular tachycardia (VT) of 150 beats/min. An intravenous bolus of lidocaine was without effect but 25 mg ajmaline converted the tachycardia to sinus rhythm. A total of 70 mg ajmaline was subsequently infused because of frequent ventricular premature systoles. During this treatment polymorphic VT with very wide QRS complexes developed, but spontaneously disappeared after ajmaline had been discontinued. The case demonstrates the need for taking into account the potential risk of a proarrhythmic effect of anti-arrhythmic drugs.
一名23岁女性因心率达150次/分钟的危及生命的单形性室性心动过速（VT）而住院。静脉注射一剂利多卡因无效，但25毫克阿马林将心动过速转为窦性心律。由于频发室性早搏，随后共输注了70毫克阿马林。在治疗期间，出现了QRS波群极宽的多形性室性心动过速，但在停用阿马林后自行消失。该病例表明，需要考虑抗心律失常药物致心律失常作用的潜在风险。
