Mletzko R, Jung W, Manz M, Lüderitz B
Medizinische Universitätsklinik, Innere Medizin--Kardiologie, Bonn.
Z Kardiol. 1991 Jul;80(7):459-62.
The hemodynamic effect of the intravenous application of ajmaline (50 mg) was studied during persistent ventricular tachycardia. With the onset of ventricular tachycardia an increase of heart rate up to 177 +/- 40 bpm and a simultaneous decrease of cardiac output from 7.1 +/- 2.7 l/min to 3.4 +/- 1.1 l/min (p less than 0.001) could be demonstrated. Ajmaline prolonged the QRS interval and slowed the ventricular tachycardia rate to 133 +/- 28 bpm. Simultaneously, an increase of cardiac output to 5.9 +/- 2.3 l/min (p less than 0.001) could be documented. A significant correlation between the increase of cardiac output and the change of ventricular tachycardia rate was found. A drug-induced termination of ventricular tachycardia by ajmaline was possible in 60% of patients. Intravenous application of ajmaline during persistent ventricular tachycardia leads to a hemodynamic improvement caused by the reduction of the tachycardia rate. This temporary stabilization of the hemodynamic status is important for emergency treatment of ventricular tachycardia.
在持续性室性心动过速期间研究了静脉注射阿义马林（50毫克）的血流动力学效应。随着室性心动过速的发作，可证明心率增加至177±40次/分钟，同时心输出量从7.1±2.7升/分钟降至3.4±1.1升/分钟（p<0.001）。阿义马林延长了QRS间期，并将室性心动过速速率减慢至133±28次/分钟。同时，可记录到心输出量增加至5.9±2.3升/分钟（p<0.001）。发现心输出量增加与室性心动过速速率变化之间存在显著相关性。60%的患者中阿义马林可药物性终止室性心动过速。持续性室性心动过速期间静脉注射阿义马林可因心动过速速率降低而导致血流动力学改善。这种血流动力学状态的暂时稳定对室性心动过速的紧急治疗很重要。
