Federal University of Rio de Janeiro, Pharmacy College, Rio de Janeiro, Brazil.
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universidad Politécnica de Valencia-Universidad de Valencia, Spain; Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain.
Photodiagnosis Photodyn Ther. 2018 Mar;21:43-49. doi: 10.1016/j.pdpdt.2017.11.003. Epub 2017 Nov 7.
The use of nanosystems as diagnosing and therapy systems is increasing each year. There are several nanosystems available and the most prominent ones are: mesoporous silica, nanoemulsion and polymeric nanoparticles. With characteristics like low toxicology, and easy-producing process they have advantages when compared with the traditional system used, as they show specific targeting, controlled release, and higher penetration. In this study we tested three different nanocarriers (polymeric nanoparticles, nanoemulsion and mesoporous silica) containing phthalocyanineas possible PDT drugs (nanodrugs). They were tested in vitro and in vivo: cells and healthy mice, respectively, in order to understand the biological behavior and reach the initial conclusions. The results in cells showed that a dose response was observed with different concentrations of the three nanocarriers. The results in animal showed that all nanosystems have potential for application in PDT, since they were able to produce a visible effect in healthy animals.
纳米系统作为诊断和治疗系统的应用每年都在增加。有几种纳米系统可供选择，其中最突出的是：介孔硅、纳米乳液和聚合物纳米粒子。与传统系统相比，它们具有低毒理学和易于生产的特点，具有特定的靶向性、控制释放和更高的穿透性等优势。在这项研究中，我们测试了三种不同的载药纳米载体（聚合物纳米粒子、纳米乳液和介孔硅），其中包含酞菁作为可能的 PDT 药物（纳米药物）。它们分别在体外和体内进行了测试：细胞和健康小鼠，以了解其生物行为并得出初步结论。细胞实验结果表明，三种纳米载体的不同浓度都观察到了剂量反应。动物实验结果表明，所有纳米系统都有可能应用于 PDT，因为它们能够在健康动物中产生可见的效果。
