Qian Jun, Gharibi Arash, He Sailing
Zhejiang University, Joint Research Center of Photonics of the Royal Institute of Technology (Sweden) and Zhejiang University, Centre for Optical and Electromagnetic Research, Zijingang Campus, Hangzhou 310058, China.
J Biomed Opt. 2009 Jan-Feb;14(1):014012. doi: 10.1117/1.3083427.
Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bioenvironment. The mesoporous silica can also ensure that the encapsulated PpIX can be well-contacted with oxygen, stimulated, and released. PpIX-encapsulated colloidal mesoporous silica nanoparticles were uptaken by tumor cells in vitro, and the effect of photon-induced toxicity was demonstrated after comparison with some control experiments. The surface of PpIX-encapsulated silica nanoparticles can be grafted with appropriate functionalized groups and conjugated with certain biomolecules for specific targeting.
合成、表征了包裹原卟啉IX（PpIX）的介孔二氧化硅纳米颗粒，并将其用于癌症的光动力疗法（PDT）。二氧化硅包封对激活光相对透明，并且可以保护PpIX免受极端生物环境诱导的变性。介孔二氧化硅还可以确保包裹的PpIX能够与氧气充分接触、受激发并释放。包裹PpIX的胶体介孔二氧化硅纳米颗粒在体外被肿瘤细胞摄取，并且在与一些对照实验比较后证明了光诱导毒性的作用。包裹PpIX的二氧化硅纳米颗粒表面可以接枝适当的官能团并与某些生物分子缀合以实现特异性靶向。
