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平衡纳米毒性与健康应用回报:囚徒困境

Balancing nanotoxicity and returns in health applications: The Prisoner's Dilemma.

作者信息

Gkika D A, Magafas L, Cool P, Braet J

机构信息

University of Antwerp, Applied Economics, Department of Engineering Management, Antwerp, Belgium; Eastern Macedonia & Thrace Institute of Technology, Hephaestus Advanced Laboratory, Kavala, Greece.

Eastern Macedonia & Thrace Institute of Technology, Electrical Engineering Department, Kavala, Greece.

出版信息

Toxicology. 2018 Jan 15;393:83-89. doi: 10.1016/j.tox.2017.11.008. Epub 2017 Nov 7.

DOI:10.1016/j.tox.2017.11.008
PMID:29127034
Abstract

Over the past 30 years, there have been significant advancements in the field of nanomaterials. The possibility to use them in applications such as cancer treatment is extremely promising; however, the toxicity of many nanomaterials as well as the high costs associated with their use is still a concern. This paper aims to study the connection between nanomaterial toxicity and cost. This synergy may be interpreted as a different version of the classic "Prisoner's Dilemma" game, which in this case attempts to explain the possible outcomes of cooperation versus conflict between science advocating for the use of high-risk, possibly toxic materials due to their high returns, and society that might be dubious about the use of high-risk materials. In an effort to create diverse evaluation methodologies, this work uses a forecast horizon to evaluate the current status and expected future of the nanomaterials market. The historical progress of each market, toxicity information, and possible returns stemming from their use is taken into account to analyze the predictions. Our results suggest various trends for the associated costs and nanotoxicity of the studied materials.

摘要

在过去30年里,纳米材料领域取得了重大进展。将它们用于癌症治疗等应用的可能性非常具有前景;然而,许多纳米材料的毒性以及与使用它们相关的高成本仍是令人担忧的问题。本文旨在研究纳米材料毒性与成本之间的联系。这种协同作用可以被解释为经典“囚徒困境”博弈的一个不同版本,在这种情况下,它试图解释因高回报而主张使用高风险、可能有毒材料的科学界与可能对使用高风险材料持怀疑态度的社会之间合作与冲突的可能结果。为了创建多样化的评估方法,这项工作使用预测期来评估纳米材料市场的现状和预期未来。考虑到每个市场的历史进展、毒性信息以及使用它们可能产生的回报,来分析预测结果。我们的结果表明了所研究材料相关成本和纳米毒性的各种趋势。

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