Baldini M, Coni E, Mantovani A, Stacchini A, Zanasi F
Laboratorio di Tossicologia ed Ecotossicologia Comparata, Istituto Superiore di Sanità, Rome, Italy.
Food Addit Contam. 1989 Jan-Mar;6(1):117-24. doi: 10.1080/02652038909373744.
The aim of this study was the evaluation of the effect of dietary imbalances on absorption and distribution of lead in the female Sprague-Dawley rat. In this note preliminary results on the relationship between blood concentrations of lead and unbalanced diets are presented. Hyperproteic, hyperglycidic, hyperlipidic and balanced diets were prepared, and most of them included 15 mg/kg lead. Blood samples were collected at day 0, 21, 36, and 95 of the diets and analyzed by anodic stripping voltammetry (ASV). Lead uptake as a function of feed consumption was found to decrease in the order: balanced, hyperproteic and hyperglycidic, hyperlipidic diet. On the other hand lead blood levels were as follows (decreasing order): hyperlipidic, hyperproteic, hyperglycidic, balanced. Further research is being carried out on the influences of dietary imbalances on whole-body distribution of lead.
本研究的目的是评估饮食不均衡对雌性斯普拉格-道利大鼠体内铅吸收和分布的影响。本报告展示了铅血浓度与不均衡饮食之间关系的初步结果。制备了高蛋白、高糖、高脂和均衡饮食，其中大部分饮食含有15 mg/kg的铅。在饮食的第0天、21天、36天和95天采集血样，并通过阳极溶出伏安法（ASV）进行分析。发现铅摄入量随饲料消耗量的变化规律为：均衡饮食＞高蛋白饮食＞高糖饮食＞高脂饮食。另一方面，血铅水平如下（降序排列）：高脂饮食＞高蛋白饮食＞高糖饮食＞均衡饮食。目前正在进一步研究饮食不均衡对铅在全身分布的影响。
