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社交焦虑障碍的注意力与解释偏差矫正治疗:一项关于疗效与协同作用的随机临床试验

Attention and interpretation bias modification treatment for social anxiety disorder: A randomized clinical trial of efficacy and synergy.

作者信息

Naim Reut, Kivity Yogev, Bar-Haim Yair, Huppert Jonathan D

机构信息

School of Psychological Sciences, Tel Aviv University, Israel.

Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.

出版信息

J Behav Ther Exp Psychiatry. 2018 Jun;59:19-30. doi: 10.1016/j.jbtep.2017.10.006. Epub 2017 Oct 24.

Abstract

BACKGROUND AND OBJECTIVES

Attention bias modification treatment (ABMT) and cognitive bias modification of interpretation (CBM-I) both have demonstrated efficacy in alleviating social anxiety, but how they compare with each other, their combination, and with a combined control condition has not been studied. We examined their relative and combined efficacy compared to control conditions in a randomized controlled trial (RCT).

METHODS

Ninety-five adults diagnosed with social anxiety disorder (SAD), were randomly allocated to 4 groups: ABMT + CBM-I control (hereafter ABMT; n = 23), CBM-I + ABMT control (hereafter CBM-I; n = 24), combined ABMT + CBM-I (n = 23), and combined control (n = 25). Treatment included eight sessions over four weeks. Clinician-rated and self-reported measures of social anxiety symptoms, functional impairment, and threat-related attention and interpretive biases were evaluated at baseline, post-treatment, and 3-month follow-up.

RESULTS

ABMT yielded greater symptom reduction as measured by both clinician-ratings (Cohen's ds = 0.57-0.70) and self-reports (ds = 0.70-0.85) compared with the CBM-I, the combined ABMT + CBM-I, and the combined control conditions. Neither of the other conditions demonstrated superior symptom change compared to the control condition. No group differences were found for functioning or cognitive biases measures.

LIMITATIONS

Limitations mainly include the mix of active and control treatments applied across the different groups. Therefore, the net effect of each of the treatments by itself could not be clearly tested.

CONCLUSIONS

Results suggest superiority of ABMT compared to CBM-I and their combination in terms of symptom reduction. Possible interpretations and methodological issues underlying the observed findings are discussed.

摘要

背景与目的

注意力偏差矫正训练(ABMT)和认知偏差矫正解释训练(CBM-I)均已证明在缓解社交焦虑方面有效,但它们之间的比较、联合使用以及与联合对照条件相比的情况尚未得到研究。我们在一项随机对照试验(RCT)中研究了它们与对照条件相比的相对疗效和联合疗效。

方法

95名被诊断为社交焦虑障碍(SAD)的成年人被随机分为4组:ABMT + CBM-I对照(以下简称ABMT;n = 23)、CBM-I + ABMT对照(以下简称CBM-I;n = 24)、联合ABMT + CBM-I(n = 23)和联合对照(n = 25)。治疗为期四周,共八节。在基线、治疗后和3个月随访时,对社交焦虑症状、功能损害以及与威胁相关的注意力和解释偏差进行临床医生评定和自我报告测量。

结果

与CBM-I、联合ABMT + CBM-I以及联合对照条件相比,ABMT在临床医生评定(Cohen's d值 = 0.57 - 0.70)和自我报告(d值 = 0.70 - 0.85)方面均能更显著地减轻症状。其他条件与对照条件相比均未显示出更优的症状变化。在功能或认知偏差测量方面未发现组间差异。

局限性

局限性主要包括不同组所应用的主动治疗和对照治疗的混合情况。因此,无法明确单独测试每种治疗的净效应。

结论

结果表明,在减轻症状方面,ABMT优于CBM-I及其联合使用。讨论了观察结果背后可能的解释和方法学问题。

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