Ahya Vivek N
Pulmonary, Allergy & Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, 9035 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Clin Chest Med. 2017 Dec;38(4):595-606. doi: 10.1016/j.ccm.2017.07.002. Epub 2017 Sep 19.
Noninfectious acute lung injury syndromes are major causes of respiratory failure and early mortality after hematopoietic stem cell transplantation (HSCT). Pulmonary edema and transfusion-related acute lung injuries are important respiratory complications seen after HSCT and in the nontransplant setting. Early transplant-specific causes of lung injury, such as idiopathic pneumonia syndrome, are reviewed. Several complications, such as drug-induced pneumonitis and cryptogenic organizing pneumonia, that occur in both the early and later time periods after HSCT are also briefly discussed. The important role of pretransplant pulmonary function testing measurements in predicting posttransplant respiratory failure is highlighted.
非感染性急性肺损伤综合征是造血干细胞移植（HSCT）后呼吸衰竭和早期死亡的主要原因。肺水肿和输血相关的急性肺损伤是HSCT后以及非移植情况下常见的重要呼吸并发症。本文综述了早期移植特异性肺损伤原因，如特发性肺炎综合征。还简要讨论了HSCT后早期和晚期均会出现的几种并发症，如药物性肺炎和隐源性机化性肺炎。强调了移植前肺功能测试指标在预测移植后呼吸衰竭方面的重要作用。
