肝肺综合征和门肺高血压：对肝移植的影响。
Hepatopulmonary Syndrome and Portopulmonary Hypertension: Implications for Liver Transplantation.
机构信息
Department of Medicine, General Internal Medicine Division, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Medicine, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 834 West Gates Building, Philadelphia, PA 19104, USA.
出版信息
Clin Chest Med. 2017 Dec;38(4):785-795. doi: 10.1016/j.ccm.2017.08.002. Epub 2017 Sep 23.
Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) represent serious pulmonary complications of advanced liver diseases. Orthotopic liver transplantation (OLT) is capable of completely resolving the underlying abnormalities associated with HPS. On the other hand, post-OLT response in patients with PoPH is less predictable, although heavily influenced by pre-OLT mean pulmonary arterial pressure. It remains the case that the opportunity to reverse 2 potentially fatal organ dysfunctions in the liver and the lung make HPS and PoPH more than worthy for further clinical investigations.
肝肺综合征（HPS）和门肺高血压（PoPH）是肝脏疾病晚期的严重肺部并发症。原位肝移植（OLT）能够完全解决与 HPS 相关的潜在异常。另一方面，OLT 后 PoPH 患者的反应不太可预测，尽管受术前平均肺动脉压的影响很大。尽管如此，有机会逆转肝脏和肺部的两种潜在致命器官功能障碍，使 HPS 和 PoPH 更值得进一步临床研究。
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