Department of Biochemical Toxicology, Chair of Toxicology, Medical College, Jagiellonian University, Kraków, Poland.
Department of Biochemical Toxicology, Chair of Toxicology, Medical College, Jagiellonian University, Kraków, Poland; Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Pharmacol Rep. 2017 Dec;69(6):1232-1239. doi: 10.1016/j.pharep.2017.06.013. Epub 2017 Jul 1.
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid function, reproductive system, and immune system. HCB as a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) is a hormonal disruptor. HCB is also known to cause tumors of the liver, thyroid and mammary gland in laboratory animals. This review presents HCB toxicity in humans and laboratory animals. The main attention was focused on the mechanisms of HCB toxicity, especially at the molecular level.
六氯苯（HCB）是一种广泛分布于环境中的有机氯农药。人类慢性暴露于 HCB 会导致多种影响，如卟啉症的触发、微粒体酶诱导、甲状腺功能障碍、神经症状和免疫紊乱。在动物中，HCB 会引起肝性卟啉症、神经毒性作用，以及对甲状腺功能、生殖系统和免疫系统的毒性作用。HCB 作为一种二恶英类似物和芳烃受体（AhR）的弱配体，是一种激素干扰物。HCB 还已知会导致实验动物的肝脏、甲状腺和乳腺肿瘤。本综述介绍了 HCB 对人类和实验动物的毒性。主要关注的是 HCB 毒性的机制，特别是在分子水平上。
