College of Animal Science and Technology, China Agricultural University, Beijing, China.
Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, and Key Laboratory of Reproduction and Genetics of Ningxia Hui Autonomous Region, School of Basic Medical Science, Ningxia Medical University, Yinchuan, China.
Front Endocrinol (Lausanne). 2022 Jun 9;13:890307. doi: 10.3389/fendo.2022.890307. eCollection 2022.
There are many organochlorine pollutants in the environment, which can be directly or indirectly exposed to by mothers, and as estrogen endocrine disruptors can cause damage to the lactation capacity of the mammary gland. In addition, because breast milk contains a lot of nutrients, it is the most important food source for new-born babies. If mothers are exposed to organochlorine pesticides (OCPs), the lipophilic organochlorine contaminants can accumulate in breast milk fat and be passed to the infant through breast milk. Therefore, it is necessary to investigate organochlorine contaminants in human milk to estimate the health risks of these contaminants to breastfed infants. In addition, toxic substances in the mother can also be passed to the fetus through the placenta, which is also something we need to pay attention to. This article introduces several types of OCPs, such as dichlorodiphenyltrichloroethane (DDT), methoxychlor (MXC), hexachlorocyclohexane (HCH), endosulfan, chlordane, heptachlorand and hexachlorobenzene (HCB), mainly expounds their effects on women's lactation ability and infant health, and provides reference for maternal and infant health. In addition, some measures and methods for the control of organochlorine pollutants are also described here.
环境中存在许多有机氯污染物，这些污染物可以通过母亲直接或间接暴露，并且作为雌激素内分泌干扰物会对乳腺的泌乳能力造成损害。此外，由于母乳含有大量营养物质，它是新生儿最重要的食物来源。如果母亲接触有机氯农药 (OCPs)，亲脂性有机氯污染物会在母乳脂肪中蓄积，并通过母乳传递给婴儿。因此，有必要调查人乳中的有机氯污染物，以评估这些污染物对母乳喂养婴儿的健康风险。此外，母亲体内的有毒物质也可以通过胎盘传递给胎儿，这也是我们需要注意的问题。本文介绍了几种 OCPs，如滴滴涕 (DDT)、甲氧滴滴涕 (MXC)、六氯环己烷 (HCH)、硫丹、氯丹、七氯和六氯苯 (HCB)，主要阐述了它们对女性泌乳能力和婴儿健康的影响，为母婴健康提供参考。此外，本文还介绍了一些控制有机氯污染物的措施和方法。
