Wen B C, Hussey D H, Staples J, Hitchon P W, Jani S K, Vigliotti A P, Doornbos J F
Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Int J Radiat Oncol Biol Phys. 1989 Jan;16(1):17-24. doi: 10.1016/0360-3016(89)90005-9.
Fifty-two patients with craniopharyngioma were seen between January 1961 and July 1986. Of these, 40 were treated with surgery alone, 8 with surgery and postoperative radiotherapy, and 3 with radiotherapy alone. One patient received no treatment. For the group treated with surgery alone, 33% (13/40) had local tumor control, 42.5% (17/40) developed major complications, and 71% (25/35) survived 5 years. With surgery and postoperative radiotherapy, 100% (8/8) had local tumor control, 25% (2/8) developed major complications, and 100% (7/7) survived 5 years. Two of the three patients treated with radiotherapy alone had local tumor control and the third was salvaged with surgery. The "complete resection" rate for 32 patients treated with radical surgery was 63% (20/32). Tumor control was achieved in 50% (10/20) of the patients treated with "complete resection" without radiotherapy, in 15% (3/20) of the patients treated with "incomplete resection" without radiotherapy, and in 100% (8/8) of the patients treated with "incomplete resection" and postoperative radiotherapy. In this series, doses of 5000-5500 cGy were as effective in achieving control as 5500-6000 or 6000-7000 cGy.
1961年1月至1986年7月期间共诊治了52例颅咽管瘤患者。其中，40例仅接受手术治疗，8例接受手术及术后放疗，3例仅接受放疗，1例未接受任何治疗。仅接受手术治疗的患者中，33%（13/40）实现了局部肿瘤控制，42.5%（17/40）发生了严重并发症，71%（25/35）存活5年。接受手术及术后放疗的患者中，100%（8/8）实现了局部肿瘤控制，25%（2/8）发生了严重并发症，100%（7/7）存活5年。仅接受放疗的3例患者中，2例实现了局部肿瘤控制，第3例通过手术挽救。32例行根治性手术的患者“完全切除”率为63%（20/32）。未接受放疗的“完全切除”患者中50%（10/20）实现了肿瘤控制，未接受放疗的“不完全切除”患者中15%（3/20）实现了肿瘤控制，接受“不完全切除”及术后放疗的患者中100%（8/8）实现了肿瘤控制。在本系列研究中，5000 - 5500 cGy的剂量在实现肿瘤控制方面与5500 - 6000 cGy或6000 - 7000 cGy同样有效。
