Hetzel F W, Avery K, Chopp M
Department of Neurology, Henry Ford Hospital, Detroit, MI.
Int J Radiat Oncol Biol Phys. 1989 Jan;16(1):183-6. doi: 10.1016/0360-3016(89)90027-8.
Following hyperthermia a dramatic drop in intra-lesional pH has occurred in a variety of experimental tumor systems. To date, no direct observations have been made that document the time course of such changes or the recovery from such changes over prolonged periods of time. These experiments were designed to measure intralesional pH as a function of time following "doses" of hyperthermia related to specific biological end points. All studies were conducted in the C3H-mammary carcinoma tumor model system. Intralesional temperature was continuously monitored throughout treatment and post treatment pH was measured with microelectrodes at several specific time points ranging from 4 hrs to 7 days. The pretreatment control value of mean pH was 6.73. At the TCD90 "dose" level the mean value of pH dropped to a level of 6.22 +/- .095 while following the TCD10 "dose" the value obtained was 6.55 +/- .148. Recovery of the pH to higher values followed similar time courses returning to maximum values approximately 3 days post treatment. The recovery, plateau levels of pH were however, separated by approximately .3 pH units with the higher "dose" curve always at lower values than that achieved following the lower "dose".
在多种实验性肿瘤系统中，热疗后瘤内pH值出现了显著下降。迄今为止，尚未有直接观察记录此类变化的时间进程或长时间内此类变化的恢复情况。这些实验旨在测量与特定生物学终点相关的热疗“剂量”作用后瘤内pH值随时间的变化情况。所有研究均在C3H-乳腺癌肿瘤模型系统中进行。在整个治疗过程中持续监测瘤内温度，并用微电极在4小时至7天的几个特定时间点测量治疗后pH值。治疗前平均pH值的对照值为6.73。在TCD90“剂量”水平时，pH平均值降至6.22±0.095，而在TCD10“剂量”作用后，得到的值为6.55±0.148。pH值恢复到较高水平遵循类似的时间进程，大约在治疗后3天恢复到最大值。然而，pH值的恢复、平稳水平相差约0.3个pH单位，较高“剂量”曲线的值始终低于较低“剂量”后的水平。
