Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Clin Chim Acta. 2018 Jan;476:28-37. doi: 10.1016/j.cca.2017.11.005. Epub 2017 Nov 10.
Pyroptosis is a pro-inflammatory form of regulated cell death and is dependent on the enzymatic activity of inflammatory proteases that belong to the family of cysteine-dependent aspartate-specific proteases (caspases). Pyroptosis is morphologically, mechanistically, and pathophysiologically distinct from other forms of cell death, including apoptosis and necrosis. Pyroptosis is characterized by rapid plasma membrane rupture, with the consequent release of intracellular contents and pro-inflammatory mediators, including interleukin (IL)-1β, IL-18, and the alarmin HMGB-1.Recent studies have shown that pyroptosis may be involved in atherosclerosis and play an important role in atherosclerotic lesion instability. Here, we review the progress made in understanding the morphological, molecular, and pathophysiological mechanisms of pyroptosis and its potential role in atherosclerosis.
细胞焦亡是一种依赖于半胱氨酸天冬氨酸蛋白酶（caspase）家族中炎性蛋白酶酶切活性的炎症性细胞程序性死亡方式。细胞焦亡在形态学、机制和病理生理学上与其他细胞死亡形式（如凋亡和坏死）不同。细胞焦亡的特征是细胞膜迅速破裂，导致细胞内物质和促炎介质（如白细胞介素（IL）-1β、IL-18 和警报素 HMGB-1）的释放。最近的研究表明，细胞焦亡可能参与动脉粥样硬化，并在动脉粥样硬化病变不稳定中发挥重要作用。本文综述了对细胞焦亡的形态学、分子和病理生理学机制及其在动脉粥样硬化中的潜在作用的研究进展。
