靶向胆固醇驱动的细胞焦亡：一种防治动脉粥样硬化的有前景策略。
Targeting cholesterol-driven pyroptosis: a promising strategy for the prevention and treatment of atherosclerosis.
作者信息
Tang Yuehong, Tong Wenjuan, Peng Yujiao, Sun Shaowei
机构信息
Institute of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Gynecology and Obstetrics, First Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
出版信息
Mol Biol Rep. 2025 May 15;52(1):459. doi: 10.1007/s11033-025-10554-8.
Funding Pyroptosis is a type of programmed cell death (PCD) pathway distinguished by inflammation. It is activated by specific inflammasomes. Once activated, it causes the physical breakdown of the cell, along with the discharge of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). Abundant evidence has demonstrated the existence of pyroptotic cell death within atherosclerotic plaques, which has significance for the development of atherosclerosis (AS). As a result, pyroptosis has become a new and important topic in cardiovascular disease (CVD) research. Cholesterol, it is recognized to have a connection with inflammation, exerts a crucial function in the development process of AS, and has been linked to the initiation of pyroptosis. This review aims to briefly summarize the fundamental aspects of pyroptosis and the influence of cholesterol-related inflammation in AS. Additionally, this review will explore potential therapeutic approaches based on pyroptosis that could be utilized for the prevention and treatment of AS.
资助 细胞焦亡是一种以炎症为特征的程序性细胞死亡（PCD）途径。它由特定的炎性小体激活。一旦激活，它会导致细胞的物理崩解，同时释放促炎细胞因子，如白细胞介素-1β（IL-1β）和白细胞介素-18（IL-18）。大量证据表明动脉粥样硬化斑块内存在细胞焦亡性细胞死亡，这对动脉粥样硬化（AS）的发展具有重要意义。因此，细胞焦亡已成为心血管疾病（CVD）研究中的一个新的重要课题。胆固醇被认为与炎症有关，在AS的发展过程中发挥着关键作用，并且与细胞焦亡的启动有关。本综述旨在简要总结细胞焦亡的基本方面以及胆固醇相关炎症在AS中的影响。此外，本综述将探讨基于细胞焦亡的潜在治疗方法，这些方法可用于AS的预防和治疗。
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